Work Package 3 

 

WP3: Mechanism of action studies (MOA) studies to establishing the in vitro and in vivo structural distribution relationships (SDRs) -- Leader: PPS (M1-M36)
WP3 includes the tasks that aim to: establish the solubility and stability of synthesised micro/nano-particles to ensure they satisfy in vitro ADMET criteria; rank systemic and central penetrability of the synthesised micro/nano-particles; clarify the mechanisms of permeability increase; map out the body distribution of selected micro/nano-particles from above studies; explore and resolve toxicity issues; establish structural distribution relationships (SDRs) of micro/nano-particles by modelling drug transport in silico.